From 2000 to 2005, he held a Research Fellowship from the Royal Academy of Engineering of the U.K. Since 2005, he has been with the Computer Science, Signals and Systems Laboratory of Sophia Antipolis (I3S), UniCA, CNRS, where he is a Full Professor. He was the Head of the "Signals, Images and Systems" (SIS) research division in 2016-2021 and he has been I3S' Deputy Director since January 2022. His research interests lie in the areas of signal processing and machine learning with emphasis on matrix and tensor factorizations, principal/independent component analysis, source separation and related techniques, including theoretical aspects and applications in biomedical problems and digital communications. From 2010 to 2014, he led an ANR-funded Young Investigator's project aiming at noninvasively predicting the outcome of the catheter ablation therapy for the treatment of atrial fibrillation, the most prevalent sustained cardiac arrhythmia. Since September 2021 he holds a Senior Chair from the Interdisciplinary Institute for Artificial Intelligence (3IA) Côte d'Azur on the topic of AI for patient-tailored atrial fibrillation ablation.

Prof. Zarzoso served as Associate Editor of the IEEE Transactions on Neural Networks and Learning Systems (2011-2015) and has been a Program Committee Member of several international conferences. He was a Program Committee Chair of the 9th International Conference on Latent Variable Analysis and Signal Separation (LVA/ICA-2010) and a keynote lecturer at the LVA/ICA-2015 Summer School. He is a Senior Member of the IEEE and an honorary member of the Institut Universitaire de France, where he was appointed in 2013-2018.